Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NOV |
| Gene Name: | NOV |
| Protein Full Name: | Protein NOV homolog |
| Alias: | CCN family member 3;Insulin-like growth factor-binding protein 9;Nephroblastoma-overexpressed gene protein homolog |
| Mass (Da): | 39162 |
| Number AA: | 357 |
| UniProt ID: | P48745; B3FHX2 |
| Locus ID: | 4856 |
| COSMIC ID: | NOV |
| Gene location on chromosome: | Xq28 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19805 |
| Percent of cancer specimens with mutations: | 0.43 |
| Deregulated by viral insertion: | Avian leukosis virus - Chicken |
| Normal role description: | NOV is small secreted cysteine-rich regulatory protein associated with the extracellular matrix and plays an important role in cell growth regulation and in the development of the cardiovascular and skeletal system, fibrosis and cancer. The gene was first identified in myeloblastosis-associated virus-1-induced avian nephroblastoma and later found to have sequence homologous expressed in normal human hematopoietic cells and in nephroblastoma. |
| Commentary on involvement of protein in cancer: | 1/101 kidney samples was also mutated (Sanger COSMIC) |