Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CD97 |
| Gene Name: | CD97 |
| Protein Full Name: | CD97 antigen |
| Alias: | CD97 molecule; Leukocyte antigen CD97; Seven transmembrane helix receptor; Seven-span transmembrane protein; Seven-transmembrane, heterodimeric receptor associated with inflammation; TM7LN1 |
| Mass (Da): | 91869 |
| Number AA: | 835 |
| UniProt ID: | P48960 |
| Locus ID: | 976 |
| COSMIC ID: | CD97 |
| Gene location on chromosome: | 19p13 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20102 |
| Percent of cancer specimens with mutations: | 0.67 |
| Normal role description: | CD97 is a G protein-coupled receptor, which may play a role in cell adhesion as well as in recruitment, activation and migration of leukocytes. It contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and CD55. CD97 enhances proteolytic activity of matrix metalloproteinases (MMPs) and secretion of chemokines in an isoform-specific manner. Overexpression of the gene promotes tumour growth. The α-chain of the longest CD97 isoform enhances angiogenesis. |
| Commentary on involvement of protein in cancer: | 1/206 breast cancer samples was also mutated ( mis-sense) |