Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PXN |
| Gene Name: | PXN |
| Protein Full Name: | Paxillin |
| Alias: | Paired box protein Pax-1; PAX-1; PAXI; Paxillin; Paxillin alpha |
| Mass (Da): | 64533 |
| Number AA: | 591 |
| UniProt ID: | P49023 |
| Locus ID: | 5829 |
| COSMIC ID: | PXN |
| Gene location on chromosome: | 12q24.23 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20269 |
| Percent of cancer specimens with mutations: | 0.32 |
| Normal role description: | PXN is a cytoskeletal protein involved in actin-membrane attachment of cell adhesion to extracellular matrix sites. It is also involved in regualtin of adhesion, motility and survival of the cell. Interactions with SRC and other molecules can induce cell motility via MAPK pathway. In lung cancer it is found to be overexpressed and contribute to cell growth, proliferation and invasion. |