Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MAPKAPK2 |
| Gene Name: | MAPKAPK2 |
| Protein Full Name: | MAP kinase-activated protein kinase 2 |
| Alias: | EC 2.7.11.1; MAP kinase-activated protein kinase 2; MAPK2; MAPKAP kinase 2; RPS6KC1 |
| Mass (Da): | 45568 |
| Number AA: | 400 |
| UniProt ID: | P49137 |
| Locus ID: | 9261 |
| COSMIC ID: | MAPKAPK2 |
| Gene location on chromosome: | 1q32.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20285 |
| Percent of cancer specimens with mutations: | 0.31 |
| Normal role description: | MAPKAPK2 is a protein-serine/threonine kinase regulated through direct phosphorylation by p38 MAPK. It is involved in a number of cellular processes such as inflammation, stress responses, nuclear export, cell proliferation, and regulation of gene expression. It mediates both ERK and p38 MAPK-dependent neutrophil responses, participates in TNFα-stimulated exocytosis of secretory vesicles in neutrophils, and plays a role in phagocytosis-induced respiratory burst activity. Another one of its major substrates is HSP27, a protein responsble for stimulating actin polymerization in order to facilitate the recovery from cytoskeleton destruction during cellular stress. Over-expression of the gene has been linked to Multiple Myeloma resistance to chemotherapy, and it has been found to play a role in neuroinflammatory and neurodegenerative diseases such as Alzheimer's. |