Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | THBS3 |
| Gene Name: | THBS3 |
| Protein Full Name: | Thrombospondin-3 |
| Alias: | TSP3 |
| Mass (Da): | 104201 |
| Number AA: | 956 |
| UniProt ID: | P49746 |
| Locus ID: | 7059 |
| COSMIC ID: | THBS3 |
| Gene location on chromosome: | 1q21 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19781 |
| Percent of cancer specimens with mutations: | 0.72 |
| Normal role description: | THBS3 is a extracellular glycoprotein which mediates cell-cell and cell-extracellular interactions. THBS3 forms a pentameric structure which are held together by inter chain disulphide linkages. Primarily mis-sense mutations of THBS3 have been detected in cancer, however these have been characterized functionally. Due to THBS3's role in promoting cell adhesion and mediating cell-cell contact dysfunction of THBS3 may contribute to increased metastasis of cancer. |