Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RanBP2 |
| Gene Name: | RANBP2 |
| Protein Full Name: | E3 SUMO-protein ligase RanBP2 |
| Alias: | 358 kDa nucleoporin; E3 SUMO-protein ligase RanBP2; Nuclear pore complex protein Nup358; Nucleoporin Nup358; NUP358; P270; RAN binding protein 2; Ran-binding protein 2; RBP2 |
| Mass (Da): | 358199 |
| Number AA: | 3224 |
| UniProt ID: | P49792 |
| Locus ID: | 5903 |
| COSMIC ID: | RANBP2 |
| Gene location on chromosome: | 2q13 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20177 |
| Percent of cancer specimens with mutations: | 1.76 |
| Deregulated in translocations: | Inflammatory myofibroblastic tumors with t(2;2)(p23;q13); 5' RANBP2 - 3' ALK |
| Normal role description: | Component of the nuclear export pathway. Facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import. Protein defects have been implicated in susceptability to necrotizing CNS infections but role in oncogenesis is unclear. |