Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GSK3B |
| Gene Name: | GSK3B |
| Protein Full Name: | Glycogen synthase kinase-3 beta |
| Alias: | EC 2.7.11.26; Factor A; Glycogen synthase kinase 3 beta; GSK-3 beta; GSK3-beta; Kinase GSK-3 beta; Kinase GSK3-beta; Protein kinase GSK-3-beta |
| Mass (Da): | 46744 |
| Number AA: | 420 |
| UniProt ID: | P49841 |
| Locus ID: | 2932 |
| COSMIC ID: | GSK3B |
| Gene location on chromosome: | 3q13.33 |
| Number of cancer specimens: | 19967 |
| Percent of cancer specimens with mutations: | 0.45 |
| Normal role description: | GSK3B is a sertine-threonin kinase that is involved in engery metabolism, neuronal development, and body pattern formation. Mutations leading to upregulation of GSK3B are implicated in ovarian, prostate, pancreatic, colorectal, neuroblastoma, and glioblastoma neoplasms, by positively regulating cyclin D1 and thus promoting cell cycle progression. |