Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KLK7 |
| Gene Name: | KLK7 |
| Protein Full Name: | Kallikrein-7 |
| Alias: | hK7 |
| Mass (Da): | 27507 |
| Number AA: | 253 |
| UniProt ID: | P49862 |
| Locus ID: | 5650 |
| COSMIC ID: | KLK7 |
| Gene location on chromosome: | 19q13.33 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.34 |
| Normal role description: | Protease - Serine. May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Also KLK7 degrades the ECM and contibutes to the formation of normal epithelium in many different organs. Normal function regulated by hormones (estrogen, progesterone, cortisol). Most cancer systems demonstrate upregulation of KLK7 in tumour compared to normal adjacent tissue although some systems have demonstrate downregulation. May contribute to locally invasive properties of malignant cells. |