Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GMPS |
| Gene Name: | GMPS |
| Protein Full Name: | GMP synthase [glutamine-hydrolyzing] |
| Alias: | Glutamine amidotransferase; GMP synthetase; GUAA; Guanine monphosphate synthetase |
| Mass (Da): | 76715 |
| Number AA: | 693 |
| UniProt ID: | P49915 |
| Locus ID: | 8833 |
| COSMIC ID: | GMPS |
| Gene location on chromosome: | 3q24 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19926 |
| Percent of cancer specimens with mutations: | 0.59 |
| Deregulated in translocations: | t(3;11)(q25;q23); fusion of MLL to GMPS; treatment related acute non lymphoblastic leukemia (M4 ANLL |
| Normal role description: | Synthesizes Guanine nucleotides and is therefore upregulated in transformed or rapidly proliferating cells. Role in oncogenesis is to provide substrate for ongoing cellular division although mutations will not drive cancer. |