Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CDKN1C |
| Gene Name: | CDKN1C |
| Protein Full Name: | Cyclin-dependent kinase inhibitor 1C |
| Alias: | BWCR; BWS; CDKN1C; CDN1C; CDNC; Cyclin-dependent kinase inhibitor p57; KIP2; P57; p57, Kip2 |
| Mass (Da): | 32177 |
| Number AA: | 316 |
| UniProt ID: | P49918 |
| Locus ID: | 1028 |
| COSMIC ID: | CDKN1C |
| Gene location on chromosome: | 11p15.5 |
| Number of cancer specimens: | 19905 |
| Percent of cancer specimens with mutations: | 0.08 |
| Mutations observed as inherited: | Beckwith-Wiedemann syndrome (BWS). |
| Gene undergoes hypermethylation: | Gastric, pancreatic, hepatic and AML. |
| Normal role description: | Cyclin-dependent kinase inhibitor, cell cycle regulator. |