Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MMP14 |
| Gene Name: | MMP14 |
| Protein Full Name: | Matrix metalloproteinase-14 |
| Alias: | EC 3.4.24.80; Matrix metallopeptidase 14 (membrane-inserted); Matrix metalloproteinase-14 precursor; Membrane-type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase; MMP- X1; MMP-14; MT1MMP; MT1-MMP; MT-MMP 1; MTMMP1 |
| Mass (Da): | 65884 |
| Number AA: | 582 |
| UniProt ID: | P50281 |
| Locus ID: | 4323 |
| COSMIC ID: | MMP14 |
| Gene location on chromosome: | 14q11.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19796 |
| Percent of cancer specimens with mutations: | 0.41 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | MMP14 is a membrane-bound metalloprotease that is involved in the degradation of the extracellular matrix. It appears to be able to trigger tumour invasion by specifically activating progelatinase A (MMP2) on the tumour cell surface. Overexpression may also be playing a role in the activation of the ERK pathway. |