Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TNFSF10 |
| Gene Name: | TNFSF10 |
| Protein Full Name: | Tumor necrosis factor ligand superfamily member 10 |
| Alias: | Apo-2 ligand;TNF-related apoptosis-inducing ligand |
| Mass (Da): | 32509 |
| Number AA: | 281 |
| UniProt ID: | P50591 |
| Locus ID: | 8743 |
| COSMIC ID: | TNFSF10 |
| Gene location on chromosome: | 3q26.31 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20150 |
| Percent of cancer specimens with mutations: | 0.3 |
| Normal role description: | TNFSF10 is a cytokine belonging to the TNF ligand family. It preferentially induces apoptosis in transformed and tumour cells, but not normal cells although it is expressed at a significant level in most normal tissues. The protein is able to bind several members of the TNF-R superfamily including TNFRSF10A/B/C/D, and possibly also TNFRSF11B. Ligand binding to any of these receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. TNFSF10 has been shown to be overexpressed in B-CLL peripheral blood mononuclear cells in comparison to normal B-cells, but B-CLL cells have been shown to be resistant to TNFSF10 -mediated apoptosis. |
| Commentary on involvement of protein in cancer: | 1/146 lung cancer samples was also mutated (Sanger COSMIC) |