Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LRBA |
| Gene Name: | LRBA |
| Protein Full Name: | Lipopolysaccharide-responsive and beige-like ancho |
| Alias: | Beige-like; Beige-like protein; BGL; CDC4L; CDC4-like; CDC4-like protein; LAB300; LBA; LPS-responsive vesicle trafficking, beach and anchor containing |
| Mass (Da): | 319108 |
| Number AA: | 2863 |
| UniProt ID: | P50851 |
| Locus ID: | 987 |
| COSMIC ID: | LRBA |
| Gene location on chromosome: | 4q31.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19690 |
| Percent of cancer specimens with mutations: | 1.9 |
| Normal role description: | May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules. Role in oncogenesis unclear |