Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SCNN1B |
| Gene Name: | SCNN1B |
| Protein Full Name: | Amiloride-sensitive sodium channel subunit beta |
| Alias: | Beta-NaCH;Epithelial Na(+) channel subunit beta;Nonvoltage-gated sodium channel 1 subunit beta;SCNEB |
| Mass (Da): | 72659 |
| Number AA: | 640 |
| UniProt ID: | P51168 |
| Locus ID: | 6338 |
| COSMIC ID: | SCNN1B |
| Gene location on chromosome: | 16p12.2-p12.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19688 |
| Percent of cancer specimens with mutations: | 0.67 |
| Normal role description: | Ion channel - sodium. Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. |