Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | STAT5B |
| Gene Name: | STAT5B |
| Protein Full Name: | Signal transducer and activator of transcription 5 |
| Alias: | STA5B |
| Mass (Da): | 89866 |
| Number AA: | 787 |
| UniProt ID: | P51692 |
| Locus ID: | 6777 |
| COSMIC ID: | STAT5B |
| Gene location on chromosome: | 17q11.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 21392 |
| Percent of cancer specimens with mutations: | 0.86 |
| Normal role description: | STAT5B is a member of the STAT family of transcription factors. STAT5B mediates the signal transduction initiated by numerous ligands, including: IL2, IL4, CSF1, and various growth hormones. STAT5B is known to play a role in a diversity of biological processes, including: T-cell receptor signalling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. STAT5B mutations have been found in mouth, skin, and ovarian tumors. |