Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | AFF1 |
| Gene Name: | AFF1 |
| Protein Full Name: | AF4/FMR2 family, member 1 |
| Alias: | AF4/FMR2 family member 1; AF4/FMR2 family, member 1, isoform CRA_b; AF4/FMR2 family, member 1, isoform CRAb; AFF1 protein; Protein FEL; Proto-oncogene AF4; Putative FelC |
| Mass (Da): | 131578 |
| Number AA: | 1211 |
| UniProt ID: | P51825 |
| Locus ID: | 4299 |
| COSMIC ID: | AFF1 |
| Gene location on chromosome: | 4q21 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19868 |
| Percent of cancer specimens with mutations: | 0.02 |
| Deregulated in translocations: | Acute leukemias. Fusion partners include Hrx. |
| Normal role description: | Transcription activator |