Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CASP5 |
| Gene Name: | CASP5 |
| Protein Full Name: | Caspase-5 |
| Alias: | ICE(rel)-III;Protease ICH-3;Protease TY |
| Mass (Da): | 49736 |
| Number AA: | 418 |
| UniProt ID: | P51878 |
| Locus ID: | 838 |
| COSMIC ID: | CASP5 |
| Gene location on chromosome: | 11q22.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19536 |
| Percent of cancer specimens with mutations: | 0.84 |
| Normal role description: | Caspase 5 is a cell death-related protease that promotes apotosis. It is regulated by interferon-gamma and lipopolysaccharides as well as others. One of its substrates is dephosphoryated Max, induced by Fas stimulation. |