Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MNAT1 |
| Gene Name: | MNAT1 |
| Protein Full Name: | CDK-activating kinase assembly factor MAT1 |
| Alias: | CAP35; CDK7/cyclin H assembly factor; Cyclin G1-interacting; MAT1; Menage a trois 1, cyclin H assembly factor; RING finger protein MAT1; RNF66 |
| Mass (Da): | 35823 |
| Number AA: | 309 |
| UniProt ID: | P51948 |
| Locus ID: | 4331 |
| COSMIC ID: | MNAT1 |
| Gene location on chromosome: | 14q23 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20057 |
| Percent of cancer specimens with mutations: | 0.23 |
| Normal role description: | MNAT1 complexes with cyclin-H and CDK7 to create the CDK-activating kinases (CAK) complex, which activates several cyclin-associated kinases. Mutations in this gene have been found in ovarian tumors. Given that this protein postively regulates the cell cycle, it is likely able, given gain of fuction mutation(s), to be oncogenic. |
| Commentary on involvement of protein in cancer: | Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. |