Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RAP1GDS1 |
| Gene Name: | RAP1GDS1 |
| Protein Full Name: | Rap1 GTPase-GDP dissociation stimulator 1 |
| Alias: | Exchange factor smgGDS;SMG GDS protein;SMG P21 stimulatory GDP/GTP exchange protein |
| Mass (Da): | 66317 |
| Number AA: | 607 |
| UniProt ID: | P52306 |
| Locus ID: | 5910 |
| COSMIC ID: | RAP1GDS1 |
| Gene location on chromosome: | 4q22.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20238 |
| Percent of cancer specimens with mutations: | 0.45 |
| Deregulated in translocations: | T cell acute lymphocytic leukemia. Fusion partners include NUP98 |
| Normal role description: | Activates GTP/GDP exchange reaction on small GTPases. |