Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | VAV2 |
| Gene Name: | VAV2 |
| Protein Full Name: | Guanine nucleotide exchange factor VAV2 |
| Alias: | Vav 2 guanine nucleotide exchange factor; Vav-2 |
| Mass (Da): | 101289 |
| Number AA: | 878 |
| UniProt ID: | P5273 |
| Locus ID: | 7410 |
| COSMIC ID: | VAV2 |
| Gene location on chromosome: | 9q34.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20338 |
| Percent of cancer specimens with mutations: | 0.66 |
| Normal role description: | VAV2 is a guanine nucleotide exchange factor (GEF). It acts on the Rho family of Ras-related GTPases. VAV2 is known to play an important role in angiogenesis. Mutations in VAV2 have been observed in ovarian tumors. |