Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PDX1 |
| Gene Name: | PDX1 |
| Protein Full Name: | Pancreas/duodenum homeobox protein 1 |
| Alias: | Glucose-sensitive factor;Insulin promoter factor 1;Insulin upstream factor 1;Islet/duodenum homeobox-1;Somatostatin-transactivating factor 1 |
| Mass (Da): | 30771 |
| Number AA: | 283 |
| UniProt ID: | P52945 |
| Locus ID: | 3651 |
| COSMIC ID: | PDX1 |
| Gene location on chromosome: | 13q12.2 |
| Cancer protein type: | OP (possibly) |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES (possibly) |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.14 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | PDX1 is a transcription factor involved in activation of insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose trnasporter type 2 transcription, particularly in glucose-dependent regulation of insulin transcription. Due to its involvement with growth factor transcription, it is likely an proto-oncogene, but its exact function in cancer has not been determined. Its expression has been noted to be elevated in various cancers such as pancreatic, breast, prostate, colorectal, kidney, and gastric cancers. |