Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NUP98 |
| Gene Name: | NUP98 |
| Protein Full Name: | Nuclear pore complex protein Nup98-Nup96 |
| Alias: | 96 kDa nucleoporin; 98 kDa nucleoporin; NU98; Nuclear pore complex protein Nup98; Nucleoporin 98kDa; Nucleoporin Nup96; Nucleoporin Nup98; NUP96 |
| Mass (Da): | 187790 |
| Number AA: | 1729 |
| UniProt ID: | P52948 |
| Locus ID: | 4928 |
| COSMIC ID: | NUP98 |
| Gene location on chromosome: | 11p15 |
| Cancer protein type: | TSP? |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 21017 |
| Percent of cancer specimens with mutations: | 1.36 |
| Deregulated in translocations: | t(1;11)(q23;p15.5):NUP98-PMX1; t(2;11)(q31;p15):NUP98-HOXD13; t(4;11)(q21;p15.5): NUP98-RAP1GDS1; t(5;11)(q35;p15.5):NUP98-NSD1; t(7;11)(p15;p15):NUP98-HOXA9; t(9;11)(p22;p15.5):NUP98-LEDGF; t(11;12)(p15;q13): NUP98-unknown; t(11;17)(p15.5;q21): N |
| Normal role description: | Derived from a 186 kDa precursor through proteolytic cleavage. Plays a role in bidirectional transport across the nucleoporin complex. Intercats directly with components of the nuclear pore.Various translocations of NUP98 involved in human malignancies. Located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. |