Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NKX2-5 |
| Gene Name: | NKX2-5 |
| Protein Full Name: | Homeobox protein Nkx-2.5 |
| Alias: | Cardiac-specific homeobox;Homeobox protein CSX;Homeobox protein NK-2 homolog E |
| Mass (Da): | 34918 |
| Number AA: | 324 |
| UniProt ID: | P52952 |
| Locus ID: | 1482 |
| COSMIC ID: | NKX2-5 |
| Gene location on chromosome: | 5q35.2 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.36 |
| Deregulated in translocations: | Chronic Lymphocytic Leukemia. Fusion partners include TCRA/TCRD |
| Normal role description: | Involve in differentiation processes in heart development and in homeostasis and survival of cardiac myocytes |