Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DAPK1 |
| Gene Name: | DAPK1 |
| Protein Full Name: | Death-associated protein kinase 1 |
| Alias: | DAP kinase 1; DAPK; Death associated protein kinase; EC 2.7.11.1; Kinase DAPK1 |
| Mass (Da): | 160073 |
| Number AA: | 1430 |
| UniProt ID: | P53355 |
| Locus ID: | 1612 |
| COSMIC ID: | DAPK1 |
| Gene location on chromosome: | 9q34.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19853 |
| Percent of cancer specimens with mutations: | 1.31 |
| Gene undergoes hypermethylation: | Lung cancer, gastric cancer, Barrett's adenocarcinomas, colon cancer and cervical cancer. |
| Normal role description: | DAPK1 is a protein-serine/threonine kinase which mediates apoptosis in response to gamma-interferon. DAPK1 role in apoptosis is the formation of autophagic vesicles and membrane blebbing. DAPK1 functions as a tumour suppressor protein in cancer and inhibition of its activity through hypermethylation or deletions can result in cancer development. Mutations which prevent DAPK1 interaction with substratres such as ERK can also prevent DAPK1 mediated apoptosis. |