Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LIMK1 |
| Gene Name: | LIMK1 |
| Protein Full Name: | LIM domain kinase 1 |
| Alias: | EC 2.7.11.1; Kinase LIMK1; KIZ-1; LIMK; LIMK-1 |
| Mass (Da): | 72585 |
| Number AA: | 647 |
| UniProt ID: | P53667 |
| Locus ID: | 3984 |
| COSMIC ID: | LIMK1 |
| Gene location on chromosome: | 7q11.23 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20136 |
| Percent of cancer specimens with mutations: | 0.55 |
| Normal role description: | LIMK1 is a protein-serine/threonine kinase. It regulates organization of cytoskeleton by inactivating phosphorylation of CFL1, CFL2, DSTN and inactivating phosphorylation on TPPP to inhibit depolymerization and destablilization of actin and tubulin. It is involved in cell motility, cell morphology, cytokinesis and cell cycle progression. Overexpression leads to developing invasive phenotype and metastasis of cancers. |