Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | AP3M2 |
| Gene Name: | AP3M2 |
| Protein Full Name: | AP-3 complex subunit mu-2 |
| Alias: | Adapter-related protein complex 3 mu-2 subunit;Clathrin assembly protein assembly protein complex 1 medium chain homolog 2;Clathrin coat assembly protein AP47 homolog 2;Clathrin coat-associated protein AP47 homolog 2;Golgi adaptor AP-1 47 kDa protein homolog 2;HA1 47 kDa subunit homolog 2;Mu3B-adaptin;P47B |
| Mass (Da): | 46977 |
| Number AA: | 418 |
| UniProt ID: | P53677 |
| Locus ID: | 10947 |
| COSMIC ID: | AP3M2 |
| Gene location on chromosome: | 8p11.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.34 |
| Found in amplified chromosomal regions in human cancers: | Part of the 8p11-12 amplicon in familial breast cancer. |
| Normal role description: | AP3M2 is a subunit of a non clathrin-associated adaptor-related protein complex (AP-3). This complex facilitates vesicle budding at the Golgi and may be involved in protein trafficking to lysosomes. |
| Commentary on involvement of protein in cancer: | No transforming mutations were identified in the Atlas of Gene Oncology, the Sanger COSMIC database, or Uniprot for this gene. |