Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MAPK12 |
| Gene Name: | MAPK12 |
| Protein Full Name: | Mitogen-activated protein kinase 12 |
| Alias: | EC 2.7.11.24; ERK5; ERK6; MAPK12; MK12; P38 MAPK-gamma; SAPK3; Stress-activated protein kinase-3 |
| Mass (Da): | 41940 |
| Number AA: | 367 |
| UniProt ID: | P53778 |
| Locus ID: | 6300 |
| COSMIC ID: | MAPK12 |
| Gene location on chromosome: | 22q13.33 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20473 |
| Percent of cancer specimens with mutations: | 0.2 |
| Normal role description: | MAPK12 is a protein-serine/threonine kinase. Part of the p38 stress pathway which prevents cell cycle progression. Many cancer cells will upregulate MAPK12 activity to kill cancer cells. Loss of function may be important to confer survival and inhibit apoptosis for tumour cells. |