Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PTTG1IP |
| Gene Name: | PTTG1IP |
| Protein Full Name: | Pituitary tumor-transforming gene 1 protein-intera |
| Alias: | C21orf1; C21orf3; PBF; pituitary tumor-transforming 1 interacting protein; pituitary tumor-transforming gene 1 protein-interacting protein; pituitary tumor-transforming gene protein binding factor; PTTG; PTTG-binding factor |
| Mass (Da): | 20324 |
| Number AA: | 180 |
| UniProt ID: | P53801 |
| Locus ID: | 754 |
| COSMIC ID: | PTTG1IP |
| Gene location on chromosome: | 21q22.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19628 |
| Percent of cancer specimens with mutations: | 0.14 |
| Normal role description: | PTTG1P directly binds to pituitary tumor-transforming gene 1 protein (PTTG1). This interaction facilitates the nuclear translocation of PTTG1 and increases the transcriptional activation of basic fibroblast growth factor (bFGF) by PTTG1. Upregulation of PTTG1P has been found in thyroid and pituitary tumors. |