Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SLC16A1 |
| Gene Name: | SLC16A1 |
| Protein Full Name: | Monocarboxylate transporter 1 |
| Alias: | Monocarboxylate transporter 1: Solute carrier family 16 member 1 |
| Mass (Da): | 53958 |
| Number AA: | 500 |
| UniProt ID: | P53985 |
| Locus ID: | 6566 |
| COSMIC ID: | SLC16A1 |
| Gene location on chromosome: | 1p12; 1p13.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.46 |
| Normal role description: | SLC16A1 is a proton gradient linked transporter - for monooxylates.Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. SLC16A1 has been found to be upregulated in many different cancers including glial, colorectal, lung, cervival and breast carcinomas. However it was also been found to be silenced or downregulated in some breast and colorectal cancers. Few mutations of SLC16A1 have been detected in cancer and its role in mediating cancer development is still unclear. |