Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PMS1 |
| Gene Name: | PMS1 |
| Protein Full Name: | PMS1 protein homolog 1 |
| Alias: | DNA mismatch repair protein PMS1; PMS1 postmeiotic segregation increased 1; PMS1 postmeiotic segregation increased 1 (S. cerevisiae); PMSL1 |
| Mass (Da): | 105830 |
| Number AA: | 932 |
| UniProt ID: | P54277 |
| Locus ID: | 5378 |
| COSMIC ID: | PMS1 |
| Gene location on chromosome: | 2q31-33 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20790 |
| Percent of cancer specimens with mutations: | 0.63 |
| Mutations observed as inherited: | Hereditary non ployposis colorectal carcinoma |
| Normal role description: | PMS1 mediates repair of DNA mismatches. |