Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | EPHA5 |
| Gene Name: | EPHA5 |
| Protein Full Name: | Ephrin type-A receptor 5 |
| Alias: | EC 2.7.1.112; EC 2.7.10.1; EHK1; Eph homology kinase-1; HEK7; Tyrosine-protein kinase receptor EHK-1 |
| Mass (Da): | 114803 |
| Number AA: | 1037 |
| UniProt ID: | P54756 |
| Locus ID: | 2044 |
| COSMIC ID: | EPHA5 |
| Gene location on chromosome: | 4q13.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 20556 |
| Percent of cancer specimens with mutations: | 2.16 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with many point mutations across entire protein, but no complex mutations, insertions or deletions. |
| Gene undergoes hypermethylation: | colorectal cancer, gastric cancer, germinal center B-cell non hodgkin lymphoma |
| Normal role description: | EPHA5 is a receptor-tyrosine kinase that is activated upon binding ephrins. It is implicated in development of nervous system, synpatogenesis and glucose stimulated insulin secretion of pancreatic islet cells. It can also be involved in cell migration and intercellular communication. |