Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | EphA4 |
| Gene Name: | EPHA4 |
| Protein Full Name: | Ephrin type-A receptor 4 |
| Alias: | EC 2.7.1.112; EC 2.7.10.1; EPH receptor A4; HEK8; Receptor protein-tyrosine kinase HEK8; SEK; TYRO1; Tyrosine-protein kinase receptor SEK |
| Mass (Da): | 109860 |
| Number AA: | 986 |
| UniProt ID: | P54764 |
| Locus ID: | 2043 |
| COSMIC ID: | EPHA4 |
| Gene location on chromosome: | 2q36.1 |
| Cancer protein type: | ?OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20448 |
| Percent of cancer specimens with mutations: | 1.28 |
| Normal role description: | EPHA4 is a receptor-tyrosine kinase that is activated upon binding ephrins. EPHA4 appears to be prodominantly involved in cell interactions in the CNS. EPHA4 is highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. . Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Upregulation of these pathways generally has been shown to promote oncogenesis. |