Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CSE1L |
| Gene Name: | CSE1L |
| Protein Full Name: | Exportin-2 |
| Alias: | Exp2 |
| Mass (Da): | 110399 |
| Number AA: | 971 |
| UniProt ID: | P55060 |
| Locus ID: | 1434 |
| COSMIC ID: | CSE1L |
| Gene location on chromosome: | 20q13.13 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19780 |
| Percent of cancer specimens with mutations: | 0.66 |
| Normal role description: | CSE1L is an export receptor for importin-α (which is responsible for transportation of proteins that carry a nuclear localization signal into the nulceus) in the presence of RanGTP, and mediates its re-export from the nucleus to the cytoplasm after import substrates have been released. It may also play a role in apoptosis and cell proliferation. |
| Commentary on involvement of protein in cancer: | * 13/27 benign melanocytic lesions stained positive for CSE1L; 5/7 lentigo maligna melanomas, 11/12 superficial spreading melanomas, 7/7 acrolentiginous and 6/6 nodular melanomas showed medium to high intensity immunoreactivity for CSE1L staining. |