Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GDF10 |
| Gene Name: | GDF10 |
| Protein Full Name: | Bone morphogenetic protein 3B |
| Alias: | Bmp3b; BMP-3b; Gdf10; Gdf10 protein; Growth differentiation factor 10; Human bone morphogenetic protein-3b |
| Mass (Da): | 53122 |
| Number AA: | 478 |
| UniProt ID: | P55107 |
| Locus ID: | 2662 |
| COSMIC ID: | GDF10 |
| Gene location on chromosome: | 10q11.22 |
| Number of cancer specimens: | 7598 |
| Percent of cancer specimens with mutations: | 0.54 |
| Commentary on involvement of protein in cancer: | The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis. |