Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MLLT10 |
| Gene Name: | MLLT10 |
| Protein Full Name: | Protein AF-10 |
| Alias: | AF10; ALL-1 fused gene from chromosome 10; Myeloid/lymphoid or mixed-lineage leukemia (trithorax) translocated to, 10; Protein AF-10 |
| Mass (Da): | 109026 |
| Number AA: | 1027 |
| UniProt ID: | P55197 |
| Locus ID: | 8028 |
| COSMIC ID: | MLLT10 |
| Gene location on chromosome: | 10p12 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19536 |
| Percent of cancer specimens with mutations: | 0.64 |
| Deregulated in translocations: | t(10;11)(p12;q23)/ANLL -->MLL-AF10; t(10;11)(p13;q14-21)-->CALM-AF10 and/or AF10-CALM |
| Normal role description: | Normal physiologic role not well identified. Translocation clearly linked to AML development. Mechanism unclear |