Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MLLT6 |
| Gene Name: | MLLT6 |
| Protein Full Name: | Protein AF-17 |
| Alias: | AF17; AF-17; ALL1 fused gene from chromosome 17 protein; FLJ23480; Myeloid/lymphoid or mixed-lineage leukemia (trithorax) translocated to, 6; Myeloid/lymphoid or mixed-lineage leukemia (trithorax) translocated to, 6 (AF17); Myeloid/lymphoid or mixed-lineage leukemia, translocated to, 6; Trithorax |
| Mass (Da): | 112076 |
| Number AA: | 1093 |
| UniProt ID: | P55198 |
| Locus ID: | 4302 |
| COSMIC ID: | MLLT6 |
| Gene location on chromosome: | 17q21 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 7695 |
| Percent of cancer specimens with mutations: | 0.1 |
| Normal role description: | MLLT6 is a poorly characterized nuclear localized transcription factor. The MLLT6 locus can participate in a translocation event to create a MLL-MLLT6 fusion protein found to be implicated in acute leukemias. MLL-MLLT6 fusion protein can function as an unregulated transcription activator. |