Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | BID |
| Gene Name: | BID |
| Protein Full Name: | BH3-interacting domain death agonist |
| Alias: | p22 BID;p15 BID;p13 BID;p11 BID |
| Mass (Da): | 21995 |
| Number AA: | 195 |
| UniProt ID: | P55957 |
| Locus ID: | 637 |
| COSMIC ID: | BID |
| Gene location on chromosome: | 22q11.21 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19535 |
| Percent of cancer specimens with mutations: | 0.13 |
| Normal role description: | The major proteolytic product p15 BID allows the release of cytochrome c. Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. |