Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TCL1A |
| Gene Name: | TCL1A |
| Protein Full Name: | T-cell leukemia/lymphoma protein 1A |
| Alias: | Uncharacterized protein |
| Mass (Da): | 13460 |
| Number AA: | 114 |
| UniProt ID: | P56279 |
| Locus ID: | 8115 |
| COSMIC ID: | TCL1A |
| Gene location on chromosome: | 14q32.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20237 |
| Percent of cancer specimens with mutations: | 0.22 |
| Deregulated in translocations: | t(14;14)(q12;q32.1): TCRA/D - TCL1 (T-cell prolymphocytic leukemia, T- cell NHL, T-cell ALL); t(7;14)(q35;q32.1): TCRB - TCL1 (T-cell prolymphocytic leukemia) |
| Normal role description: | Functions as coactivator of AKT kinases and promotes translocation of AKT1 to the nucleus. Implicated in cell proliferation and survival. Overexpression associated with development of mature T cell leukaemia. |