Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TMPRSS3 |
| Gene Name: | TMPRSS3 |
| Protein Full Name: | Transmembrane protease serine 3 |
| Alias: | Serine protease TADG-12;Tumor-associated differentially-expressed gene 12 protein |
| Mass (Da): | 49405 |
| Number AA: | 454 |
| UniProt ID: | P57727 |
| Locus ID: | 64699 |
| COSMIC ID: | TMPRSS3 |
| Gene location on chromosome: | 21q22.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19688 |
| Percent of cancer specimens with mutations: | 0.42 |
| Normal role description: | TMPRSS3 belongs to the serine protease family, and it is expressed in fetal cochlea and other tissues. It acts as a regulator of cochlear hair-cell survival and activation. Mutations in this gene have been observed in ovarian tumors. Upregulation of this gene has been observed in both ovarian and pancreatic tumors. |