Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TCTA |
| Gene Name: | TCTA |
| Protein Full Name: | T-cell leukemia translocation-altered gene protein |
| Alias: | T-cell leukemia translocation-associated gene protein |
| Mass (Da): | 11341 |
| Number AA: | 103 |
| UniProt ID: | P57738 |
| Locus ID: | 6988 |
| COSMIC ID: | TCTA |
| Gene location on chromosome: | 3p21.31 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.09 |
| Deregulated in translocations: | Translocation (1;3)(p32;p21) --> TAL1-TCTA in T-ALL |
| Normal role description: | TCTA is a membrane protein that may be required for cellular fusion during osteoclastogenesis. Translocation of the gene with TAL1 have been observed in T-ALL. |