Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SESN2 |
| Gene Name: | SESN2 |
| Protein Full Name: | Sestrin-2 |
| Alias: | DKFZp761M0212; Hi95; Hypoxia induced gene 95; SES2; SEST2; Sestrin 2 |
| Mass (Da): | 54494 |
| Number AA: | 480 |
| UniProt ID: | P58004 |
| Locus ID: | 83667 |
| COSMIC ID: | SESN2 |
| Gene location on chromosome: | 1p35.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.44 |
| Normal role description: | SESN2 is a reductase that is involved in the reduction of peroxiredoxins. May regulate cell growth and survival and responses to cellular stress. Overexpression led to apoptosis in vitro, whereas SESN2 seemed to protect breast cancer cells from apoptosis. |