Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SPINK7 |
| Gene Name: | SPINK7 |
| Protein Full Name: | Serine protease inhibitor Kazal-type 7 |
| Alias: | Esophagus cancer-related gene 2 protein |
| Mass (Da): | 9232 |
| Number AA: | 85 |
| UniProt ID: | P58062 |
| Locus ID: | 84651 |
| COSMIC ID: | SPINK7 |
| Gene location on chromosome: | 5q32; 5q33.1 |
| Cancer protein type: | TSP? |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.08 |
| Normal role description: | SPINK7 is a membrane localized protein involved in the inhibition of trypsin-like serine proteases. SPINK7 has found to be expressed in liver, lung, esophagus and lung tissues. Complete loss of SPINK7 expression has been implicated in the development of metastatic esophageal cancers. SPINK7 may function to inhibit extracellular proteases to prevent metastasis of tumours. No mutations of SPINK7 have been identified to indicate deletion or silencing mutations. This would classify SPINK7 as a putative tumour suppressor protein. |