Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LOXL3 |
| Gene Name: | LOXL3 |
| Protein Full Name: | Lysyl oxidase homolog 3 |
| Alias: | Lysyl oxidase-like protein 3 |
| Mass (Da): | 83166 |
| Number AA: | 753 |
| UniProt ID: | P58215 |
| Locus ID: | 84695 |
| COSMIC ID: | LOXL3 |
| Gene location on chromosome: | 2p13.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.64 |
| Normal role description: | LOXL3 is a member of the lysyl oxidase family and is importants for the biogenesis of connective tissue. It is an extracellular Copper-dependent amine oxidase responsible for catalyzing the first step in the formation of collagen-elastin cross-links. It may also play a role in developmental regulation, senescence, cell growth control, and chemotaxis via its N-terminus domains. It has been found to interact with SNAI1 to downregulate E-cadherin expression, and overexpression of the proten in MDCK epithelial cells induces an epithelial-mesenchymal transition process. |
| Commentary on involvement of protein in cancer: | Only 1 ovarian sample was included in Sanger COSMIC |