Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RAC3 |
| Gene Name: | RAC3 |
| Protein Full Name: | Ras-related C3 botulinum toxin substrate 3 |
| Alias: | Rac3; Ras-related c3 botulinum toxin substrate 3 (rho family, small gtp binding protein rac3) |
| Mass (Da): | 21379 |
| Number AA: | 192 |
| UniProt ID: | P60763 |
| Locus ID: | 5881 |
| COSMIC ID: | RAC3 |
| Gene location on chromosome: | 17q25.3 |
| Cancer protein type: | ?OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.13 |
| Normal role description: | RAC3 is a monomeric g-protein Involved in cytoskeletal interactions. Interacts with the bcr/abl oncogene as well as c-jun transcription factor. Some experiments with constituently activated RAC3 demonstrate tumorogenesis in breast tissue implying its role as a potential proto-oncogene. |