Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RAB8A |
| Gene Name: | RAB8A |
| Protein Full Name: | Ras-related protein Rab-8A |
| Alias: | MEL; Oncogene c-mel; RAB8; RAB8A, member RAS oncogene family; Ras-related protein Rab-8A |
| Mass (Da): | 23668 |
| Number AA: | 207 |
| UniProt ID: | P61006 |
| Locus ID: | 4218 |
| COSMIC ID: | RAB8A |
| Gene location on chromosome: | 19p13.1 |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.15 |
| Commentary on involvement of protein in cancer: | May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. |