Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CKS1B |
| Gene Name: | CKS1B |
| Protein Full Name: | Cyclin-dependent kinases regulatory subunit 1 |
| Alias: | CKS-1; PNAS-18 (CDC28 protein kinase regulatory subunit 1B, isoform CRA_c) (CDC28 protein kinase regulatory subunit 1B) |
| Mass (Da): | 9660 |
| Number AA: | 79 |
| UniProt ID: | P61024 |
| Locus ID: | 1163 |
| COSMIC ID: | CKS1B |
| Gene location on chromosome: | 1q21.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19742 |
| Percent of cancer specimens with mutations: | 0.05 |
| Normal role description: | CKS1B is a protein-serine/threonine kinase - regulatory subunit. Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. Amplification and overexpression is associated with poor prognosis in various cancers. May inhibit apoptosis through the MEK-Erk pathway in breast cancer cells. |