Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Rap1b |
| Gene Name: | RAP1B |
| Protein Full Name: | Ras-related protein Rap-1b |
| Alias: | DKFZp586H0723; GTP-binding protein smg p21B; K-REV; OK/SW- cl.11; RAL1B; RAP1B, member of RAS oncogene family; RAPB; ras-related protein Rap-1b; smg 21B |
| Mass (Da): | 20825 |
| Number AA: | 184 |
| UniProt ID: | P61224 |
| Locus ID: | 5908 |
| COSMIC ID: | RAP1B |
| Gene location on chromosome: | 12q14 |
| Cancer protein type: | OP (possibly) |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES (possibly) |
| Number of cancer specimens: | 20338 |
| Percent of cancer specimens with mutations: | 0.18 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | RAP1B is a Ras superfamily GTP-binding protein that has intrinsic GTPase activity. It contributes to the establishment and maintenance of correct endothelial cell polarity. It is activated by the GTPase-activating protein RAP1GAP and EPAC2. Its role in cancer is not well understood, but it may be able to activate the B-Raf kinase and the MEK-ERK cascade leading to cell proliferation. It may also have a role in the regulation of integrin-mediated cell adhesion. Knockdown of expression has been shown to reduce HUVEC migration and integrin-dependent adhesion. |