Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RAP2B |
| Gene Name: | RAP2B |
| Protein Full Name: | Ras-related protein Rap-2b |
| Mass (Da): | 20486 |
| Number AA: | 183 |
| UniProt ID: | P61225 |
| Locus ID: | 5912 |
| COSMIC ID: | RAP2B |
| Gene location on chromosome: | 3q24 |
| Number of cancer specimens: | 20338 |
| Percent of cancer specimens with mutations: | 0.12 |
| Commentary on involvement of protein in cancer: | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells. |