Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FGF12 |
| Gene Name: | FGF12 |
| Protein Full Name: | Fibroblast growth factor 12 |
| Alias: | FGF-12; FGF12B; FHF1; FHF-1; Fibroblast growth factor 12B; Fibroblast growth factor FGF-12b; Fibroblast growth factor homologous factor 1; Fibroblast growth factorous factor 1; Myocyte-activating factor |
| Mass (Da): | 27399 |
| Number AA: | 243 |
| UniProt ID: | P61328 |
| Locus ID: | 2257 |
| COSMIC ID: | FGF12 |
| Gene location on chromosome: | 3q28 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20058 |
| Percent of cancer specimens with mutations: | 0.57 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | FGF12 is a growth factor likely to be involved in nervous system development and function, but the specific function has not been determined. FGF family members typically have mitogenic and pro-survival properties and thus have been associated with tumour growth. It is likely to act through receptor tyrosine kinase signalling. |