Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | HNRNPK |
| Protein Full Name: | Heterogeneous nuclear ribonucleoprotein K |
| Alias: | 65 kDa phosphoprotein; CSBP; DC-stretch binding protein; HnRNP-K; HNRPK; Transformation upregulated nuclear protein; TUNP |
| Mass (Da): | 50976 |
| Number AA: | 463 |
| UniProt ID: | P61978 |
| Locus ID: | 3190 |
| Gene location on chromosome: | 9q21.32 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.45 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | HNRNPK is a pre-mRNA-binding protein that binds to poly-C sequences on RNA and ssDNA. It plays a role in the nuclear metabolism of heterogeneous nuclear RNAs, especially those pre-mRNAs with cytidine-rich sequences. It may function to influence pre-mRNA processing, metabolism and transport. Evidence suggests it may also have a role in cell cycle progression, and accumulation of HNRNPK was associated with cell migration and metastasis. Higher expressions have been noted in esophageal cancer, colorectal cancer, lung cancer, and nasopharyngeal carcinoma. |